v4.99.86 eJukebox.exe replaced over the old one and relaunced. The splash screen didn't complete after several minutes, so tried again - same thing.

Rebooted vista and now I immediately get error message "Invalid Picture". Clicking the OK button on this dialogue closes eJ

What I failed to mention was that during the reboot cycle, two Microsoft updates were applied. Restored system to previous restore point (without the MS automatic updates) and all now works